:root {
    --bg-color: #ffffff;
    --text-color: #000000;
    --border-color: #000000;
    --accent-color: #000000;
    --text-muted: #555555;
    
    --spacing-sm: 1rem;
    --spacing-md: 2rem;
    --spacing-lg: 4rem;
    --spacing-xl: 8rem;
    
    --container-width: 1000px;
}

* {
    box-sizing: border-box;
    margin: 0;
    padding: 0;
}

body {
    font-family: 'Inter', sans-serif;
    background-color: var(--bg-color);
    color: var(--text-color);
    line-height: 1.6;
    -webkit-font-smoothing: antialiased;
    font-size: 16px;
}

.container {
    max-width: var(--container-width);
    margin: 0 auto;
    padding: 0 var(--spacing-md);
}

/* TYPOGRAPHY */
h1 {
    font-size: 5rem;
    font-weight: 900;
    line-height: 1;
    letter-spacing: -0.05em;
    margin-bottom: var(--spacing-md);
    text-transform: uppercase;
}

h2 {
    font-size: 2.5rem;
    font-weight: 800;
    letter-spacing: -0.03em;
    margin-bottom: var(--spacing-md);
    padding-bottom: var(--spacing-sm);
    border-bottom: 2px solid var(--border-color);
    text-transform: uppercase;
}

h3 {
    font-size: 1.2rem;
    font-weight: 800;
    margin-bottom: 0.5rem;
    text-transform: uppercase;
    letter-spacing: 0.02em;
}

h4 {
    font-size: 1.1rem;
    font-weight: 800;
    margin-bottom: 0.5rem;
}

p {
    font-size: 1.125rem;
    color: var(--text-color);
    margin-bottom: 1.5rem;
    font-weight: 400;
}

.eyebrow {
    font-size: 0.85rem;
    font-weight: 600;
    letter-spacing: 0.1em;
    margin-bottom: var(--spacing-md);
    display: inline-block;
    border: 1px solid var(--border-color);
    padding: 0.4rem 1rem;
    border-radius: 50px;
}

.highlight {
    font-weight: 800;
    border-bottom: 2px solid var(--border-color);
}

.sub-heading {
    font-size: 0.9rem;
    color: var(--text-muted);
    margin-top: -0.5rem;
    margin-bottom: 1rem;
}

/* NAVIGATION */
.nav-bar {
    padding: var(--spacing-md) 0;
    border-bottom: 1px solid var(--border-color);
    position: sticky;
    top: 0;
    background: var(--bg-color);
    z-index: 100;
}

.nav-inner {
    display: flex;
    justify-content: space-between;
    align-items: center;
}

.nav-logo {
    font-weight: 900;
    font-size: 1.2rem;
    letter-spacing: -0.03em;
    color: var(--text-color);
    text-decoration: none;
    line-height: 1;
}

.nav-links {
    display: flex;
    gap: clamp(0.75rem, 1.25vw, 1.5rem);
    align-items: center;
}

.nav-links a {
    display: inline-flex;
    align-items: center;
    color: var(--text-color);
    text-decoration: none;
    font-weight: 600;
    font-size: clamp(0.75rem, 1.1vw, 0.85rem);
    text-transform: uppercase;
    letter-spacing: 0.05em;
    position: relative;
    white-space: nowrap;
    line-height: 1;
}

.nav-links a::after {
    content: '';
    position: absolute;
    width: 100%;
    height: 1px;
    bottom: -4px;
    left: 0;
    background-color: var(--border-color);
    transform: scaleX(0);
    transform-origin: right;
    transition: transform 0.3s ease;
}

.nav-links a:hover::after {
    transform: scaleX(1);
    transform-origin: left;
}

/* DROPDOWN NAVIGATION */
.nav-dropdown {
    position: relative;
    display: inline-flex;
    align-items: center;
}

.dropdown-trigger {
    display: inline-flex;
    align-items: center;
    gap: 0.35rem;
    line-height: 1;
}

.dropdown-arrow-svg {
    width: 8px;
    height: 8px;
    transition: transform 0.25s cubic-bezier(0.4, 0, 0.2, 1);
    display: inline-block;
    vertical-align: middle;
}

.nav-dropdown:hover .dropdown-arrow-svg {
    transform: rotate(180deg);
}

.dropdown-content {
    position: absolute;
    top: 100%;
    left: 50%;
    transform: translateX(-50%) translateY(10px);
    background-color: #ffffff;
    border: 1px solid #000000;
    min-width: 280px;
    box-shadow: 0 10px 30px rgba(0, 0, 0, 0.08);
    z-index: 1000;
    opacity: 0;
    visibility: hidden;
    transition: transform 0.2s cubic-bezier(0.4, 0, 0.2, 1), opacity 0.2s ease, visibility 0.2s ease;
    padding: 0.5rem 0;
    margin-top: 0.5rem;
}

.dropdown-content::before {
    content: '';
    position: absolute;
    top: -10px;
    left: 0;
    width: 100%;
    height: 10px;
    background: transparent;
}

.nav-dropdown:hover .dropdown-content {
    opacity: 1;
    visibility: visible;
    transform: translateX(-50%) translateY(0);
}

.dropdown-content a,
.dropdown-content a:visited {
    color: #000000;
    background-color: #ffffff;
    padding: 0.6rem 1.25rem;
    text-decoration: none;
    display: block;
    font-size: 0.75rem;
    text-transform: uppercase;
    font-weight: 600;
    letter-spacing: 0.05em;
    transition: background-color 0.15s ease, color 0.15s ease;
}

.dropdown-content a::after {
    display: none !important;
}

.dropdown-content a:hover,
.dropdown-content a:focus {
    background-color: #000000;
    color: #ffffff;
}

/* SECTIONS */
.hero-section {
    padding: var(--spacing-xl) 0 var(--spacing-lg);
    border-bottom: 1px solid var(--border-color);
}

.hero-subtitle {
    font-size: 1.5rem;
    line-height: 1.4;
    max-width: 800px;
    font-weight: 500;
}

.section-container {
    padding: var(--spacing-lg) 0;
    border-bottom: 1px solid var(--border-color);
}

.content-block {
    max-width: 800px;
    margin-bottom: var(--spacing-lg);
}

/* GRIDS */
.data-grid {
    display: grid;
    grid-template-columns: repeat(3, 1fr);
    gap: var(--spacing-md);
    margin-bottom: var(--spacing-lg);
}

.data-column {
    border-top: 2px solid var(--border-color);
    padding-top: var(--spacing-sm);
}

.diagnostic-grid .data-column {
    border-top: 1px dashed var(--border-color);
}

/* STATS */
.stat-block {
    margin-top: 1.5rem;
    display: flex;
    flex-direction: column;
}

.stat-value {
    font-size: 3rem;
    font-weight: 900;
    line-height: 1;
    letter-spacing: -0.03em;
}

.stat-label {
    font-size: 0.75rem;
    font-weight: 600;
    letter-spacing: 0.1em;
    text-transform: uppercase;
    margin-top: 0.5rem;
}

.massive-stat .stat-value {
    font-size: 6rem;
}

.highlight-glow {
    position: relative;
    display: inline-block;
}

.highlight-glow::after {
    content: '';
    position: absolute;
    bottom: 10px;
    left: -5%;
    width: 110%;
    height: 30%;
    background-color: rgba(0,0,0,0.1);
    z-index: -1;
}

/* SPLIT CONTENT */
.split-content {
    display: flex;
    gap: var(--spacing-lg);
    align-items: center;
    max-width: 100%;
}

.split-left {
    flex: 1;
}

.split-right {
    flex: 1;
    display: flex;
    justify-content: flex-end;
}

/* EVIDENCE SLIDER */
.evidence-slider {
    position: relative;
    margin-top: var(--spacing-md);
}

.slider-track {
    display: flex;
    gap: var(--spacing-md);
    overflow-x: auto;
    scroll-snap-type: x mandatory;
    scroll-behavior: smooth;
    -webkit-overflow-scrolling: touch;
    scrollbar-width: none;
    padding-bottom: var(--spacing-sm);
}

.slider-track::-webkit-scrollbar {
    display: none;
}

.slider-slide {
    flex: 0 0 85%;
    scroll-snap-align: start;
    border: 1px solid var(--border-color);
    padding: var(--spacing-md);
}

.slider-slide .insight-block {
    display: grid;
    grid-template-columns: 1.2fr 1fr;
    gap: var(--spacing-md);
    align-items: start;
}

.insight-main-row {
    display: grid;
    grid-template-columns: 1.2fr 1fr;
    gap: var(--spacing-md);
    align-items: start;
}

.insight-text {
    width: 100%;
}

.insight-video {
    width: 100%;
}

.slider-slide .video-card {
    width: 100%;
}

/* Comments Section */
.insight-comments-section {
    border-top: 1px solid var(--border-color);
    padding-top: var(--spacing-md);
    margin-top: var(--spacing-md);
}

.insight-comments-section h4 {
    font-family: SFMono-Regular, Consolas, 'Liberation Mono', Menlo, monospace;
    font-size: 0.75rem;
    font-weight: 800;
    letter-spacing: 0.05em;
    text-transform: uppercase;
    margin-bottom: var(--spacing-sm);
    color: var(--text-color);
}

.comments-grid {
    display: grid;
    gap: var(--spacing-md);
}

.comments-grid.col-1 {
    grid-template-columns: 1fr;
}

.comments-grid.col-2 {
    grid-template-columns: 1fr 1fr;
}

.comments-grid.col-3 {
    grid-template-columns: 1fr 1fr 1fr;
}

.comment-card {
    border: 1px solid var(--border-color);
    padding: var(--spacing-md);
    background-color: rgba(0, 0, 0, 0.01);
}

.comment-card.blockquote-style {
    border-left: 3px solid var(--text-color);
    padding-left: var(--spacing-lg);
    background: none;
    border-top: none;
    border-right: none;
    border-bottom: none;
}

.comment-author {
    font-family: SFMono-Regular, Consolas, 'Liberation Mono', Menlo, monospace;
    font-weight: 800;
    font-size: 0.7rem;
    letter-spacing: 0.05em;
    text-transform: uppercase;
    color: var(--text-color);
    margin-bottom: 0.5rem;
    display: block;
}

.comment-card p {
    font-style: italic;
    font-size: 0.85rem;
    line-height: 1.45;
    color: var(--text-muted);
    margin: 0;
}

.comment-card.blockquote-style p {
    font-size: 0.95rem;
    line-height: 1.5;
}

/* Slider Controls */
.slider-controls {
    display: flex;
    align-items: center;
    justify-content: center;
    gap: 1.5rem;
    padding: 1.5rem 0 0.5rem;
}

.slider-arrow {
    background: none;
    border: 1px solid var(--border-color);
    width: 40px;
    height: 40px;
    font-size: 1.1rem;
    cursor: pointer;
    display: flex;
    align-items: center;
    justify-content: center;
    transition: all 0.15s ease;
    color: var(--text-color);
    font-family: 'Inter', sans-serif;
}

.slider-arrow:hover {
    background: var(--text-color);
    color: var(--bg-color);
}

.slider-dots {
    display: flex;
    gap: 0.5rem;
    align-items: center;
}

.slider-dot {
    width: 10px;
    height: 10px;
    border-radius: 50%;
    border: 1px solid var(--border-color);
    background: transparent;
    cursor: pointer;
    padding: 0;
    transition: all 0.2s ease;
}

.slider-dot.active {
    background: var(--text-color);
    transform: scale(1.3);
}

/* VIDEO SELECTOR TABS */
.video-selector-container {
    display: flex;
    flex-direction: column;
    gap: var(--spacing-sm);
    margin-top: var(--spacing-sm);
}

.video-selector-tabs {
    display: flex;
    flex-wrap: wrap;
    gap: 0.5rem;
    margin-bottom: var(--spacing-sm);
    border-bottom: 1px solid var(--border-color);
    padding-bottom: 0.5rem;
}

.video-tab-btn {
    background: none;
    border: 1px solid var(--border-color);
    color: var(--text-color);
    padding: 0.4rem 0.8rem;
    font-family: SFMono-Regular, Consolas, 'Liberation Mono', Menlo, monospace;
    font-size: 0.75rem;
    cursor: pointer;
    transition: all 0.2s ease;
    text-transform: uppercase;
    letter-spacing: 0.05em;
}

.video-tab-btn:hover {
    background-color: rgba(0, 0, 0, 0.05);
}

.video-tab-btn.active {
    background-color: var(--text-color);
    color: var(--bg-color);
    border-color: var(--text-color);
}

/* VIDEO CARDS */
.video-card {
    display: block;
    text-decoration: none;
    color: var(--text-color);
    border: 1px solid var(--border-color);
    transition: all 0.2s ease;
    background-color: var(--bg-color);
    position: relative;
    overflow: hidden;
}

.video-thumbnail {
    width: 100%;
    height: 180px;
    border-bottom: 1px solid var(--border-color);
    overflow: hidden;
    position: relative;
    background-color: #f5f5f5;
}

.video-thumbnail img {
    width: 100%;
    height: 100%;
    object-fit: cover;
    filter: grayscale(100%) contrast(110%) brightness(0.9);
    transition: all 0.3s ease;
}

.video-content {
    padding: 1.5rem;
}

.video-card:hover {
    transform: translateY(-2px);
    box-shadow: 0 4px 0 var(--border-color);
}

.video-card:hover .video-thumbnail img {
    filter: grayscale(0%) contrast(100%) brightness(1);
}

.video-meta {
    display: flex;
    gap: 0.5rem;
    margin-bottom: 1rem;
}

.video-type, .video-lang {
    font-size: 0.7rem;
    font-weight: 800;
    letter-spacing: 0.05em;
    padding: 0.2rem 0.5rem;
    border: 1px solid var(--border-color);
    border-radius: 3px;
}

.video-channel {
    font-size: 0.9rem;
    margin-bottom: 0;
    margin-top: 0.5rem;
    opacity: 0.8;
}

.video-pair {
    display: grid;
    grid-template-columns: 1fr 1fr;
    gap: var(--spacing-md);
    align-items: start;
}

.pathway-grid {
    display: grid;
    grid-template-columns: 1fr 1fr;
    gap: var(--spacing-lg) var(--spacing-md);
    margin-bottom: var(--spacing-lg);
}

/* CASCADE TIMELINE (INUFUSA) */
.cascade-timeline {
    border-left: 2px solid var(--border-color);
    padding-left: var(--spacing-md);
    margin-left: 1rem;
    display: flex;
    flex-direction: column;
    gap: var(--spacing-md);
}

.cascade-step {
    position: relative;
}

.cascade-number {
    position: absolute;
    left: calc(var(--spacing-md) * -1 - 1.2rem);
    top: 0;
    background-color: var(--bg-color);
    border: 2px solid var(--border-color);
    width: 2.2rem;
    height: 2.2rem;
    border-radius: 50%;
    display: flex;
    align-items: center;
    justify-content: center;
    font-weight: 900;
    font-size: 0.9rem;
}

.loop-step .cascade-number {
    background-color: var(--text-color);
    color: var(--bg-color);
}

.cascade-content {
    padding-bottom: 1rem;
}

.cascade-content h4 {
    margin-top: 0.2rem;
    text-transform: uppercase;
}

/* TREATMENT HIERARCHY */
.treatment-list {
    display: flex;
    flex-direction: column;
}

.treatment-item {
    display: flex;
    gap: var(--spacing-md);
    padding: var(--spacing-md) 0;
    border-top: 1px solid var(--border-color);
}

.treatment-rank {
    font-size: 3rem;
    font-weight: 900;
    line-height: 1;
    color: var(--text-muted);
}

.treatment-content {
    flex: 1;
}

.treatment-content h4 {
    font-size: 1.5rem;
    margin-bottom: 0.5rem;
    text-transform: uppercase;
}

.evidence-tag {
    display: inline-block;
    font-size: 0.75rem;
    font-weight: 800;
    letter-spacing: 0.05em;
    padding: 0.3rem 0.6rem;
    background-color: var(--text-color);
    color: var(--bg-color);
    text-transform: uppercase;
    margin-top: 0.5rem;
}

/* CALLOUTS */
.callout-block {
    border: 2px solid var(--border-color);
    padding: var(--spacing-md);
    margin-top: var(--spacing-md);
    position: relative;
}

.callout-block::before {
    content: '';
    position: absolute;
    top: 5px;
    left: 5px;
    width: 100%;
    height: 100%;
    background-color: transparent;
    border: 2px solid var(--border-color);
    z-index: -1;
}

.callout-label {
    font-size: 0.8rem;
    font-weight: 800;
    letter-spacing: 0.1em;
    text-transform: uppercase;
    margin-bottom: 1rem;
    border-bottom: 1px solid var(--border-color);
    padding-bottom: 0.5rem;
    display: inline-block;
}

/* LISTS */
.research-points {
    list-style: none;
}

.research-points li {
    font-size: 1.125rem;
    margin-bottom: 1rem;
    padding-left: 1.5rem;
    position: relative;
}

.research-points li::before {
    content: '→';
    position: absolute;
    left: 0;
    font-weight: 800;
}

/* RESPONSIVE */
@media (max-width: 768px) {
    h1 { font-size: 3.5rem; }
    h2 { font-size: 2rem; }
    
    .data-grid {
        grid-template-columns: 1fr;
    }

    .split-content {
        flex-direction: column;
        align-items: flex-start;
    }

    .split-right {
        justify-content: flex-start;
    }
    
    .nav-links {
        display: none; /* simple mobile handling */
    }
    
    .slider-slide {
        flex: 0 0 90%;
    }

    .insight-main-row {
        grid-template-columns: 1fr;
        gap: var(--spacing-md);
    }
    
    .comments-grid {
        grid-template-columns: 1fr !important;
    }
    
    .video-pair,
    .pathway-grid {
        grid-template-columns: 1fr;
    }
    
    .treatment-item {
        flex-direction: column;
        gap: var(--spacing-sm);
    }
}
/* =========================================
   GLOSSARY TOOLTIP PATTERN
   ========================================= */
.glossary-term {
    border-bottom: 1px dotted var(--text-color);
    cursor: help;
    position: relative;
    font-weight: 500;
}

.glossary-term::after {
    content: attr(data-tooltip);
    position: absolute;
    bottom: 100%;
    left: 50%;
    transform: translateX(-50%) translateY(-10px);
    background-color: var(--text-color);
    color: var(--bg-color);
    padding: var(--spacing-sm) var(--spacing-md);
    border-radius: 4px;
    font-family: 'Space Grotesk', sans-serif;
    font-size: 0.8rem;
    font-weight: 400;
    line-height: 1.4;
    white-space: normal;
    width: max-content;
    max-width: 300px;
    opacity: 0;
    visibility: hidden;
    transition: all 0.2s ease;
    z-index: 100;
    pointer-events: none;
    box-shadow: 0 10px 20px rgba(0,0,0,0.1);
}

.glossary-term::before {
    content: '';
    position: absolute;
    bottom: 100%;
    left: 50%;
    transform: translateX(-50%);
    border: 6px solid transparent;
    border-top-color: var(--text-color);
    opacity: 0;
    visibility: hidden;
    transition: all 0.2s ease;
    z-index: 100;
}

.glossary-term:hover::after,
.glossary-term:hover::before {
    opacity: 1;
    visibility: visible;
    transform: translateX(-50%) translateY(0);
}

/* NEW 2-COLUMN LAYOUTS FOR SLIDES AND RESEARCHER VIDEOS */
.insight-layout {
    display: grid;
    grid-template-columns: 1.2fr 1fr;
    gap: var(--spacing-md);
    align-items: start;
}

.insight-left {
    display: flex;
    flex-direction: column;
}

.insight-right {
    display: flex;
    flex-direction: column;
    gap: var(--spacing-sm);
}

.insight-right h4 {
    font-family: SFMono-Regular, Consolas, 'Liberation Mono', Menlo, monospace;
    font-size: 0.75rem;
    font-weight: 800;
    letter-spacing: 0.05em;
    text-transform: uppercase;
    margin-bottom: 0.5rem;
}

.comments-stack {
    display: flex;
    flex-direction: column;
    gap: var(--spacing-sm);
}

.video-pair-layout {
    display: grid;
    grid-template-columns: 1.2fr 1fr;
    gap: var(--spacing-md);
    align-items: stretch;
    margin-top: 3rem;
}

.video-side {
    display: flex;
    flex-direction: column;
    gap: var(--spacing-md);
}

.video-side .video-card {
    flex-grow: 1;
    display: flex;
    flex-direction: column;
}

.video-side .video-card .video-thumbnail {
    flex-grow: 1;
    height: auto;
    min-height: 200px;
}

.protocol-side {
    display: flex;
    flex-direction: column;
    gap: var(--spacing-md);
}

.dietary-guidelines-box {
    border: 1px solid var(--border-color);
    padding: var(--spacing-md);
    background-color: var(--bg-color);
}

.dietary-guidelines-box h4 {
    font-family: SFMono-Regular, Consolas, 'Liberation Mono', Menlo, monospace;
    font-size: 0.75rem;
    font-weight: 800;
    letter-spacing: 0.05em;
    text-transform: uppercase;
    margin-bottom: var(--spacing-sm);
}

.dietary-guidelines-box p {
    font-size: 0.95rem;
    color: var(--text-muted);
    font-style: italic;
    line-height: 1.45;
}

.testimonies-stack {
    display: flex;
    flex-direction: column;
    gap: var(--spacing-sm);
}

.testimonies-stack h4 {
    font-family: SFMono-Regular, Consolas, 'Liberation Mono', Menlo, monospace;
    font-size: 0.75rem;
    font-weight: 800;
    letter-spacing: 0.05em;
    text-transform: uppercase;
    margin-bottom: 0.5rem;
}

@media (max-width: 768px) {
    .slider-slide .insight-block,
    .insight-layout,
    .video-pair-layout {
        grid-template-columns: 1fr;
    }
}

/* ONSET HYPOTHESES SECTION */
.hypotheses-grid {
    display: grid;
    grid-template-columns: repeat(4, 1fr);
    gap: var(--spacing-md);
    margin-top: 3rem;
}

.hypothesis-card {
    border: 1px solid var(--border-color);
    background-color: var(--bg-color);
    display: flex;
    flex-direction: column;
    height: 100%;
    transition: transform 0.2s ease;
}

.hypothesis-card:hover {
    transform: translateY(-2px);
}

.hypothesis-image {
    width: 100%;
    aspect-ratio: 16 / 10;
    overflow: hidden;
    border-bottom: 1px solid var(--border-color);
}

.hypothesis-image img {
    width: 100%;
    height: 100%;
    object-fit: cover;
    filter: grayscale(100%) contrast(110%);
    transition: filter 0.3s ease;
}

.hypothesis-card:hover .hypothesis-image img {
    filter: grayscale(0%) contrast(100%);
}

.hypothesis-content {
    padding: var(--spacing-md);
    display: flex;
    flex-direction: column;
    flex-grow: 1;
}

.hypothesis-num {
    font-family: SFMono-Regular, Consolas, monospace;
    font-size: 0.65rem;
    color: var(--text-muted);
    font-weight: 800;
    margin-bottom: 0.5rem;
    display: block;
}

.hypothesis-content h3 {
    margin-top: 0;
    margin-bottom: 0.5rem;
    font-size: 1.1rem;
    font-weight: 800;
    letter-spacing: -0.02em;
}

.hypothesis-trigger {
    font-size: 0.8rem;
    margin-bottom: 1rem;
    padding-bottom: 0.5rem;
    border-bottom: 1px solid var(--border-color);
    font-weight: 600;
}

.hypothesis-text {
    font-size: 0.85rem;
    line-height: 1.45;
    color: var(--text-muted);
    margin: 0;
}

/* RESPONSIVE ONSET HYPOTHESES */
@media (max-width: 1200px) {
    .hypotheses-grid {
        grid-template-columns: repeat(2, 1fr);
    }
}

@media (max-width: 768px) {
    .hypotheses-grid {
        grid-template-columns: 1fr;
    }
}